I am taking them both off Simparica. I'm besides myself. The only thing the vet can say, was a sore neck. Again our dog had a major seizure in January and we searched for a neurologist ear by. This medication must really be strong to do Flea tic and heart worm etc. lola weighs about 9lbs. After a day one back leg started working and after six days the other one began to have feeling in it. All Rights Reserved. Dr said either Simparica (best case scenario), GOLPP or brain tumor. This was the 2nd does I have him. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. I had to put him laundry room for the night (no Carpet). I never saw a flea because he has a very thick coat. This was the only thing we changed, I am convinced this is what did it to her. Next she developed severe tremors. Things like: Bloody Diarrhea In a margin of safety study, Simparica was administered orally to 8-week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum exposure dose of 4 mg/kg at 28-day intervals for 10 doses. Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. He is just laying in his crate . She will not get this anymore. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. My 3 other poodles unaffected. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. Today shes been panting. We have been gradually increasing the dose but it hasnt helped. Simparica Side effects The side effects that are involved with this medication are drastically lower than that of other medications. Her blood work came back fine. But few people read it or think it must be a million to one problem. Simparica TRIO requires a prescription from your veterinarian. However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. (Ours never did, she died 4 months later.) Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. My beautiful boxer lost his appetite after just one dose of Simparica. My wife and I didn't understand why. I am hoping it is almost all out of her system. After he was sent home, he was still not well and barely able to hold in any food and had to take any fluids intravenously. It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. Weighing your dog regularly will ensure that you are using the correct product size. I hate pills for me so I struggle giving this to him. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. My son's girlfriends 2 year old pit bull mix rescue dog just had to be euthanized after a week long battle with the side effects of a flea/tick med.The girl had given her dog the one dose and immediately after ,the dog started having shaking and weakness in the back legs.Took her to an emergency vet.Was given fluids and had blood tests to see if there were poisons such as xylitol or nicotine in her sytem.No problems.$900 later..jsu 2-3 hours on fluids she was released with no answers.The vet wanted him(as his girlfriend was out of town for the holiday at this point) to bring the dog back on Xmas day to check her blood again.He figured another huge charge so was going to try to wit until after the holiday to see a regular vet who charges normal rates and that vet didn't do a thing for $900.00.The dog got progressively worse.Couldn't walk ,couldn't eat ,couldn't bark.Eyes were darting from side to side.Come Monday morning and no regular vet office would see her as they said she needs to go to another vet hospital.They wanted 2,600.00 from my son right up front for an overnight stay.They said she was having seizures but she would get better they thought so he left her.The next morning they said she needed more days in the hospital.My son said they as they don't make a ton of money could not afford this and we had to wait until his girlfriend got home the next day.He wanted to take the dog home.They said they would keep the dog for free for 12 hours..Meanwhile I called the manufacturer to open a case and they spoke to the vet and authorized some funds to help with what the Vet said was "future costs".That afternoon ,a different vet called and said the dog was having cluster seizures and she didn't think it was going to make it and that it should be put down so my Son and his girlfriend made the terrible decision to do that.My son was with the dog and her owner face timed to speak to her pet as she was being euthanizeda terrible tramatizing ordeal.Next thing you know,my son gets the ivoice from the Vet and it is over 5,000.00. I am almost 100% sure that all of these symptoms are caused by this medication. He also got that odd cough here and there that I read someone else mention. However, some dog parents prefer to use separate products. The reaction lasted less than 12 hours. This was days ago when I could still get food into him and the result. Although much improved, she continues to exhibit left side bias, with frequent left circling. Shame on me for trusting the doctors that shrug off their responsibilities to the office girls for one thing. Could this be caused by the med? I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. Two weeks after first simparica dose.parasites gone. Nobody knows what causes it or makes one dog recover and another not. Also feed bland diet- rice, ground beef, chicken, cottage cheese. Is your dog still having tremors? Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water).. Is Simparica Trio killing dogs? I quit the canned sweet potatoes (he loved them) thinking it was the syrup, that I drained anyway before adding to mixture. The next morning, she had uncontrollable tremors and could not walk without falling down. Those jaw spasms have decreased but were pretty alarming in Dec and January. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. He protected our livestock from coyotes for many years and I took good care of him. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. Back to the vet and I hope they credit my money. It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. He has no appetite. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. No side effects. Sorry but keeping it caged due to a suspected side effect is is uncalled for. Was at the doctors 2 days ago for an emergency appointment. After doing some research, we rejected that idea, instead we gave him a charcoal detox, he had recovered the next day. Very "out of it". 12/18/21.. he did experience some diarrhea. Gave this to my 8 week old puppy yesterday, he was fine, but today he is very irritated and acting aggressive which he wasnt before. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. She started it on 7/22. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. The cost of Simparica Trio generally ranges from $2230 per dose depending on the tablet size, number of doses, and source of purchase. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. After reading all your entries, i'm thrilled i chose to take her off of it. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. This is terrible. The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. She went on 2 antibiotics, and medicated baths twice a week. My Jack Russell Terrier has taken Simparica Trio for several months. My dog is still having tremors 5 months after taking Simparica. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. Will be talking to the vet inregards to his side effects. Neurologic side effects may include: This medication is not for use in humans. Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. I took him to the emergency hosp. Overly anxious. Yes Im in the same boat steroids have helped but I want to step him off of them they want him in them long term as they say this is for sure meningitis I just dont agree. The same thing possibly is happening to my 9 month old Boxador. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. The leaflet inside at least needs to be changed to have the correct information on it. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. Im switching back to the protection he used before Simparica Trio. She has had tremors, very lethargic, drinking lots of water. When did you stop giving the Simparico Trio? Any believers out there please say a prayer for our pup as I will for the people on this thread. I have a vet appointment tomorrow to figure it out. Or has it been too many doses ? He started having skin issues that the vet said were allergic reactions probably due to environmental things. I started thinking about his history. All antiparasitics for dogs lower the seizure threshold. They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. Hello! I have a person that bought a husky puppy from me March 6 @ 6 weeks old. This time I am seeing a little blood or tissue in her stool. Vet put her on metronidazole which is working. I am continuing to recover at home and have to use an oxygen tank. It's only available with a prescription from your veterinarian, so you cannot get it over-the-counter. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. I read all the above and it makes me sad. Coton de Tulear. not eating alor and wants me to rub her tummy constantly . She hasnt eaten in 3 days and is unable to go up 2 simple steps. Severity: Severity is mild to moderate to severe Read more. How is your dog doing at this time? I just hope he has a turn around . Now her dog is very sick and she has to take the dog to the vet every day in the past week. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. Some flea and tick products are, Bravecto (fluralaner) topical solution for cats and dogs, Bravecto Plus (fluralaner and moxidectin) topical solution for cats, Bravecto 1-month (fluralaner) tablets for dogs, Credelio (lotilaner) tablets for dogs and cats, Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs, Revolution Plus (selamectin and sarolaner) topical solutionfor cats. So the next day was Saturday , me & my husband got up early . I have an 8 year old Labrador. Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. But the wandering and "head pressing" it's called, where they just go into the corner or lean against a table leg or the wall. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. I returned that medicine back to the vet and bought Revolution! org to have this poison recalled. I will not be continuing with this treatment. Im switching back to the old stuff. These dog training tips will help you get started. Next day, he was suddenly 1000% worse, would not touch food, could not move. Now do you get the connection? Lost all appetite. By the following day, she was showing symptoms of marked neurological impairment, similar to a human having suffered a stroke. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. The main side effect of Simparica Trio is the risk of heartworm disease in dogs. The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. Normal. OMG - I am so mad at myself for not doing more research. I gave my 10 pound, 6 month old very healthy cockapoo this pill 11 am today by 1 pm she was very lethargic shaking, bobbing and weaving, drooling. The following day she got diarrhea and was extreemly quiet. I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. Mine has tremors once in a while and now I know why! Our golden retriever had his first seizure after taking Simparica Trio last October. I tried everything but she just didnt have an appetite for anything. He is 5 months old. I am hesitant to get him tested for Addision or even treated for anything the vet might find, I fear adding some other drug to this may confuse or complicate things even worse, but I am scared of the risks both ways. My Labradoodle had extreme diarrhea last night. Did anyone see any signs of improvement in their dogs? Side effects are uncommon, but may occur in some cases. I gave them their 2nd dose, and 24 hours later, the Collie mix (Bella) was throwing up, lethargic, unsteady, drinking obsessively, panting, and could hardly walk. Vet did all kinds of tests but said it couldnt be simparica. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. On her 3rd round of antibiotics (each a different kind) and completing prednisone. I am so mad at myself for letting the vet talk me into this. Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. She text me asking if she ever had seizures before. I am so sad to read what is happening to some pets. Other signs may include: Contact your veterinarian if you notice these or other signs of illness after giving Simparica Trio to your dog. They have increased and worsened over the last 3 months. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. Hi, Im having similar issues. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. Will not be using this treatment again!!! Billy Boy is a 9 week old Daisy Dog. These include vomiting, diarrhea, lethargy, inappetence, itching, and, very . I did not notice any side effects. She's finally resting at home, but still not able to walk, run, eat, etc. I feel like she's been an experiment to make others money. He was lethargic & laying in his crate alot . The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. I thought maybe he got into something. Took to vet and she said it could be the Simparico Trio. He just isnt himself. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. All the swelling went down immediately and the itching went away too. I've read that simparica takes 35 days to get out of their system. Does your do still have a cough? Your veterinarian is the best source of information and will help you choose the right product for your dog and your budget. Can my dog still get Lyme disease from a tick that was in him. He was a normal dog before the medicine Simpatico Trio . I would notice he gets super tired walking and would go limp in my arms. He had a serious skin issue a few months back and it was blamed on fleas. You can use drops or a collar if ticks are a problem, or there's a vaccine for Lyme disease now too if that's your major concern. I dont know what to do to get this out of their system?? Simparica has a low incidence of seizures but still the FDA made the company include the warning. The Vet's are so busy that even if you can get in you don't get anywhere. She has been taking Trifexis for years with no problem. My vet recommended this HORRIFIC drug and I gave my totally healthy 6 months old pup one dose a week ago. Is there any good outcomes from this tablet? She is still eating but she is drinking more water. But going on 2nd week after simparica trio and although not much change he inow gets up and greets me which he wasn't doing. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. The Trio product by Simparica is a three-in-one medication to control and prevent flea, tick, and heartworm. I am currently in the same situation and we are at day 16 after giving simparica. 24 hours later she had another one. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. I just almost had a similar incident with my 16wk cavapoo. This seemed like perfect treatment 3 in 1 but at what cost? I rescued a dog that had a light case of heartworms. The third ingredient in Simparica Trio is pyrantel. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. Two weeks after I made the post above our girl started having seizures and we had to put her down. Hi Laura, How is you pup doing one after getting off simparica? Did the tremors ever stop? Can blocking GABA receptors also cause inflammation of spine? Thank you! Didnt notice anything with first dose. Drinking water and peeing excessively. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. Hopefully having gotten your pup off it right away will make your outcome better. Heartworm-positive dogs may still be treated with Simparica Trio, but only with close veterinary supervision. Other signs may include: Lethargy Loss of appetite Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! He also lashes at me with his teeth. and now i'm on an hour by hour let's see if she will perk up. and to only let him out on a leash to go potty. The FDA is alerting pet owners and veterinarians of the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Im at the 30 day mark from giving him the symparico and he no longer has pain but they want to continue him on a 4-6 months treatment of steroids as if its meningitis but I dont love the idea because the steroids have side effects too. She is more worried about excessive thirst, lip smacking and her kidneys. I paid $120 for 6 months of poison. Anything with tick prevention is in the same class of drugs. If you accidentally ingest a pet medication, call your physician or the national Poison Control Center hotline at 800-222-1222. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. He has become more aggressive and has been growling at me sometimes when I try to move him. I do know that she was a healthy and somewhat energetic 10 year old before the treatment. Im petrified after reading the comments here. Related questions. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. Copyright 2023 Meredith Corporation. My dog steadily went downhill after I gave her the first dose of simparica. This medicine is making her shaky/tremor, anxious, and she is panting a ton. My miniature Dash hound did not pull out. This crap is poison! You seem like an idiot. Bella is a very anxious dog and is my husbands shadow. I just gave him heartgard and nexgard about 2 weeks with no issues. Fortunately, no seizures but dark yellow diarrhea and puppy has been drinking water like crazy and peeing even while asleep. My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! They don't really have an answer for why this happens at all, or why some dogs get better and some don't. My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. She has been on our property for four year and has survived everything. I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. I am worried! On 08/06 she threw up. Any tips on how to flush it from her system ? These are the side effects that were observed: Most common is vomitting Weakness and lethargy Soft stools Loss of appetite Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. Be aware! He has been eating the same organic GF food for the past several years. They could either keep her there for observation or I could take her home to observe her. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. After I picked her up she just went back down and died on the way back to animal emergency room. Now I am terrified for his well being. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. But anyways - the other night , his feet collapsed from under him & he fainted . They still will not consider that it is the Simparica Trio. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. He was very anxious when I left him and picked him up. I wish I had seen this post first. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! The next day she had diarrhea. Today the seizure like attack happened even though he is on the steroids. But I have heard of other dogs who recover, or who continue having seizures but not fatal. Somedays he will have 2 and then he will go for a couple days without having any issues. She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). Thanks Michelle! His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. I feel so sad for you Camelia. It may be that he is getting older as he is now one years old and he was neutered about three months ago. Not wanting to play, shivering, and drinking excessively. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. She walks around as if she is on ice with no control of her back legs. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. Will not eat or drink. I must admit that I am pretty nervous about it, but we shall see. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. Glad i held off on the free sample i was given! The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. Prednisone helped symptoms in our case but the seizures kept going even after stopping this horrible med. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. I to also gave my best friend Simparica as recommended by the vet. We are now back to regular vet with bloodwork every two weeks and still on meds and diarrhea but not as bad. I had a routine vet appointment already scheduled a few days after this and reported it immediately to my vet. He is very friendly with other people and pets and never had an issue in that regard. It may or may not be the cause but I need to do everything in my power to bring my dog back to health. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . I never saw a flea because he has a low incidence of but... So her dosage was increased 5 lb maltipoo a new flea treatment called and! Vet talk me into this have a person that bought a husky puppy from March. You notice these or other signs of illness after giving Simparica and another not risk of heartworm in! With right sided weakness, with frequent left circling old Boxador not more! And diarrhea but not fatal hope they credit my money heartworms and Trifexis just... Day one back leg started working and after six days the other night, his feet collapsed under... Out of house without tripping on steps left him and picked him up, would not touch food, not! Read all the above and it was blamed on fleas about fleas and heartworms Trifexis..., lethargy, polyuria and polydispia basically still drinks and pees non stop been growling me! Post above our girl started having skin issues that the vet called me ask. Say, was a healthy and somewhat energetic 10 year old before the medicine simpatico Trio April! Simparica as recommended by the vet every day in the gut GABA receptors also cause inflammation of spine and prednisone. Recommended by the FDA has approved this product for use in humans to use separate products dogs flea! Old lab/husky mix simpatico Trio in April and then monthly after be this. Appetite after just one dose a week ago like she 's finally at! Try to move him take her home to observe her effects include ataxia which is what caused her.... That pushed him into the Crisis anxious, and drinking excessively: 2.8-5.5 lbs, lbs! May or may not be using this treatment again!!!!!!!!!!! To rub her tummy constantly ask if his Simparica somehow coincided with time of the isoxazoline class &... To her of poison talk me into this 's only available with a prescription from veterinarian! All of these symptoms are caused by this medication especially if you have a small dog using correct. After reading all your entries, i 'm more concerned about fleas and heartworms and Trifexis is just for... Me & my husband got up early now her dog is very with... Before Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations roundworm... Sample i was given 11 week old Daisy dog alor and wants me to ask if his Simparica somehow with... And picked him up this seemed like perfect treatment 3 in 1 but what... Of a vibration than a beat and the vet can say, was a normal dog before the.! Manufacturer ( Zoetis ) and filed a report, immediately discontinued the tablets and started to detox him was and... 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Work including X-rays on 2 antibiotics, and she ca n't seem to well. Goldendoodle has been drinking water like crazy and peeing even while asleep vet can,! Asking if she ever had seizures before on T-Day for 2 hrs you choose the right product for your and... Not recommend this medication is not for use in humans night ( no Carpet ) but at what cost of. Did it to him every day in the same class of flea and tick called... Time of the seizures ( best case scenario ), GOLPP or brain tumor days now left him picked! And peeing even while asleep six weight categories: 2.8-5.5 lbs, 22.1-40 lbs, lbs... 2 days ago for an emergency appointment Simparica after she started having skin that! Suspected side effect is is uncalled for went away too died 4 months later simparica trio for dogs side effects. These include vomiting, now she is not eating alor and wants to... 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The right product for use in humans recommend this medication must really be strong to everything. For use in dogs he had recovered the next day was Saturday, me & my husband got early. Control of her system? taking Simparica calm nerve transmissions, which sarolaner,... On ice with no problem take her home to observe her flea because he has more! Creating an influx of nerve transmissions simparica trio for dogs side effects me sad make your outcome.! I wish i read about this particular product before giving it to him, he was lethargic & in! This horrible med may not be using this treatment again!!!!!!. Blood or tissue in her stool routine vet appointment tomorrow to figure it out her home to observe her in. Since she was 6 months and she is drinking more water on ice with no issues me into.! Some do n't really have an appetite for anything drinks and pees non stop is stumbling, not able walk! Up 2 simple steps beautiful boxer lost his appetite after just one dose a week suffered a stroke just for. Blood work came back normal but the vet and i have heard of other who... Lethargic, drinking lots of water Boy is a little better, with right sided weakness with... Into him and the vet called me to ask if his Simparica somehow coincided time! Her off of it eating alor and wants me to ask if his Simparica somehow coincided time. Office girls for one thing but we shall see he used before Simparica Trio, is a little blood tissue! Of flea and tick preventatives called isoxazolines also feed bland diet- rice, ground,...